If you are having such a high list of close friends and joined some multitude of groups than you might have some difficulty with the notices. I recognize this since much of my friends are addicted to playing those Facebook games and also I obtained a lot of notifications of invitations and requests.
Not taking way too much time with my own problem I would like to share what I am doing to quit those notices.
Stop Notifications On Facebook
STEPS
1. Go to your Facebook account.
2. Click the "Alert". Where you get all your notices.
3. You could see establishing option there. Select it.
4. Currently pick when you desire alert.
5. Select your Option and minimize your listing of notices.
Those are the steps that you have to do. Well with this trick you can not quit all notice but it will definitely lower the number of the notifications. In my instance it lowered to the 40-50%. So it is worth to try to stop to some pointless applications and game alerts.